Genotype Imputation for Latinos Using the HapMap and 1000 Genomes Project Reference Panels.

摘要: Genotype imputation is a vital tool in genome-wide association studies (GWAS) and meta-analyses of multiple GWAS results. Imputation enables researchers to increase genomic coverage pool data generated using different genotyping platforms. HapMap samples are often employed as the reference panel. More recently, 1000 Genomes Project resource becoming primary source for panels. Multiple targeting Latinos, most populous fastest growing minority group US. However, genotype resources Latinos rather limited compared individuals European ancestry at present, largely because lack good data. One choice panel one derived from population Mexican Los Angeles contained Phase 3 project Project. detailed evaluation quality imputed genotypes public panels has not yet been reported. Using simulation studies, Illumina OmniExpress Angles Latino Eye Study MACH software package, we evaluated accuracy Latinos. Our results show that AMR+CEU+YRI provides highest also including Asian can reduce accuracy. We provide each autosomal chromosome serve guide future imputation-based analysis