Cyclosporin A and tacrolimus induce renal Erk1/2 pathway via ROS-induced and metalloproteinase-dependent EGF-receptor signaling.
作者： El-Sayed Akool , Stefan Gauer , Bashier Osman , Anke Doller , Sebastian Schulz
DOI: 10.1016/J.BCP.2011.11.001
关键词:
摘要: … All cell culture media and supplements were purchased from Life… Due to the fact that we could not detect HB-EGF in the … the absence or presence of either N-acetyl cysteine (NAC, 5 mM) …
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Rezzani R, Exploring cyclosporine A-side effects and the protective role-played by antioxidants: the morphological and immunohistochemical studies Histology and Histopathology. ,vol. 21, pp. 301- 316 ,(2006) , 10.14670/HH-21.301
El-Sayed Akool, Anke Doller, Andrea Babelova, Wasiliki Tsalastra, Kristin Moreth, Liliana Schaefer, Josef Pfeilschifter, Wolfgang Eberhardt, Molecular Mechanisms of TGFβ Receptor-Triggered Signaling Cascades Rapidly Induced by the Calcineurin Inhibitors Cyclosporin A and FK506 Journal of Immunology. ,vol. 181, pp. 2831- 2845 ,(2008) , 10.4049/JIMMUNOL.181.4.2831
Z. Yan, S. Winawer, E. Friedman, Two different signal transduction pathways can be activated by transforming growth factor beta 1 in epithelial cells. Journal of Biological Chemistry. ,vol. 269, pp. 13231- 13237 ,(1994) , 10.1016/S0021-9258(17)36823-0
Wolfgang Eberhardt, Andrea Huwiler, Karl-Friedrich Beck, Sebastian Walpen, Josef Pfeilschifter, Amplification of IL-1β-Induced Matrix Metalloproteinase-9 Expression by Superoxide in Rat Glomerular Mesangial Cells Is Mediated by Increased Activities of NF-κB and Activating Protein-1 and Involves Activation of the Mitogen-Activated Protein Kinase Pathways Journal of Immunology. ,vol. 165, pp. 5788- 5797 ,(2000) , 10.4049/JIMMUNOL.165.10.5788
Norbert Prenzel, Esther Zwick, Henrik Daub, Michael Leserer, Reimar Abraham, Christian Wallasch, Axel Ullrich, EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF Nature. ,vol. 402, pp. 884- 888 ,(1999) , 10.1038/47260
M J Mihatsch, K Morozumi, B Ryffel, Y Yamaguchi, V Nickeleit, M Kyo, The side-effects of ciclosporine-A and tacrolimus. Clinical Nephrology. ,vol. 49, pp. 356- 363 ,(1998)
Steffan Ho, Neil Clipstone, Luika Timmermann, Jeffrey Northrop, Isabella Graef, David Fiorentino, Jamie Nourse, Gerald R Crabtree, The mechanism of action of cyclosporin A and FK506 Immunology Today. ,vol. 13, pp. 136- 142 ,(1992) , 10.1016/0167-5699(92)90111-J
Chunyou Wang, Abdulla K. Salahudeen, CYCLOSPORINE NEPHROTOXICITY : ATTENUATION BY AN ANTIOXIDANT-INHIBITOR OF LIPID PEROXIDATION IN VITRO AND IN VIVO Transplantation. ,vol. 58, pp. 940- 946 ,(1994) , 10.1097/00007890-199410270-00014
Tsukasa Takemura, Yuka Murata, Satoshi Hino, Mitsuru Okada, Hidehiko Yanagida, Masaru Ikeda, Kazuo Yoshioka, Heparin-binding EGF-like growth factor is expressed by mesangial cells and is involved in mesangial proliferation in glomerulonephritis. The Journal of Pathology. ,vol. 189, pp. 431- 438 ,(1999) , 10.1002/(SICI)1096-9896(199911)189:3<431::AID-PATH460>3.0.CO;2-I
Bashier Osman, Anke Doller, El-Sayed Akool, Martin Holdener, Edith Hintermann, Josef Pfeilschifter, Wolfgang Eberhardt, Rapamycin induces the TGFβ1/Smad signaling cascade in renal mesangial cells upstream of mTOR Cellular Signalling. ,vol. 21, pp. 1806- 1817 ,(2009) , 10.1016/J.CELLSIG.2009.07.016