Active ingredients in Chinese medicines promoting blood circulation as Na+/K+-ATPase inhibitors

摘要: The positive inotropic effect of cardiac glycosides lies in their reversible inhibition on the membrane-bound Na+/K+-ATPase human myocardium. Steroid-like compounds containing a core structure similar to are found many Chinese medicines conventionally used for promoting blood circulation. Some them demonstrated be inhibitors and thus putatively responsible therapeutic effects via same molecular mechanism as glycosides. On other hand, magnesium lithospermate B danshen is also proposed exert its by effectively inhibiting Na+/K+-ATPase. Theoretical modeling suggests that number hydrogen bonds strength hydrophobic interaction between effective ingredients various residues around binding pocket crucial inhibitory potency these active ingredients. Ginsenosides, ginseng sanqi, substantially inhibit when sugar moieties attached only C-3 position steroid-like structure, equivalent Their abolished, however, linked C-6 or C-20 steroid nucleus; presumably, attachments lead steric hindrance entrance ginsenosides into Neuroprotective glycosides, several compounds, against ischemic stroke have been accordingly observed cortical brain slice-based assay model, cumulative data support could potential drugs treatment stroke.