The role of organic volatile profiles in clinical diagnosis.

摘要: The organic volatile constituents of biological fluids contain clinically useful diagnostic information for the recognition metabolic disorders in man. To gain access to this information, it was necessary develop methodology reproducibly stripping trace concentrations volatiles from (dynamic headspace, gas phase-stripping, solvent extraction, and transevaporator technique), separate complex extracts by high-resolution capillary column chromatography, computer-aided data-handling pattern-recognition techniques analyzing immense amount generated. normal pathological identified chromatography--mass spectrometry urine, serum, breast milk are tabulated. Clinical applications above study diagnosis diabetes mellitus, respiratory virus infection, renal insufficiency, cancer described.