VEGF Targeting Agents in Ovarian Cancer

摘要: Angiogenesis, the formation of new blood vessels, is a critical component in growth and metastasis cancers has been recognized as an attractive target for anticancer therapy (Ferrara, 2002). Among pro-angiogenic factors, vascular endothelial factor (VEGF) predominant mediator angiogenesis tumor cells (Ferrara & Kerbel, 2005). As VEGF overexpressed most ovarian cancers, pathway promising anti-angiogenic against cancer (Burger, 2011). Recent increases our understanding molecular pathways that control have led to development novel VEGF-targeting agents treatment In addition inhibiting neo-vascularization, antiangiogenic are also believed normalize intratumoral vessels. Intratumoral vessels hyperpermeable, leading interstitial hypertension impaired perfusion tumors. Normalization vasculature results reduction pressure improved delivery oxygen, nutrients, cytotoxic Many these evaluated clinical trials, some them shown activity this article, we review emerging strategies treating provide information about latest studies employed treatments cancer.