Humoral and cell-mediated immune responses to live recombinant BCG–HIV vaccines

作者: Anna Aldovini , Richard A. Young

DOI: 10.1038/351479A0

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摘要: Several viral and bacterial live recombinant vaccine vehicles are being developed to produce a new generation of vaccines against broad spectrum infectious diseases. The human tuberculosis Mycobacterium bovis bacillus Calmette-Guerin (BCG) has features that make it particularly attractive vehicle. BCG other mycobacteria highly effective adjuvants, the immune response been studied extensively. With nearly two billion immunizations, long record safe use in man. It is one few can be given at birth, engenders long-lived responses with only single dose, there worldwide distribution network experience vaccination. Recently molecular genetic tools methods for have provided means introduce foreign genes into BCG. Here we report variety immunodeficiency virus type 1 polypeptides expressed recombinants under control mycobacterial hsp70 promoter produced induce antibody T-cell responses. These results demonstrate used as vehicle pathogen proteins by bacillus.

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