Lysophosphatidic acid induces neurite branch formation through LPA3
作者： Daisuke Furuta , Masayuki Yamane , Toshifumi Tsujiuchi , Ryutaro Moriyama , Nobuyuki Fukushima
DOI: 10.1016/J.MCN.2012.03.006
关键词:
摘要: Abstract Although neurite branching is crucial for neuronal network formation after birth, its underlying mechanisms remain unclear. Here, we demonstrate that lysophosphatidic acid (LPA) stimulates through a novel signaling pathway. Treatment of cell lines with LPA resulted in branch when LPA3 receptor was introduced. The effects were blocked by inhibition Gq signaling. Furthermore, expression inhibitory mutants the small GTPase Rnd2/Rho7 or an Rnd2 effector rapostlin abolished LPA3-mediated branching. agonist 2(S)-OMPT also induced axonal hippocampal neurons, which and pathway knockdown. These findings suggest involving LPA3, Gq, may play important role formation.
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