Response to sorafenib in a pediatric patient with papillary thyroid carcinoma with diffuse nodular pulmonary disease requiring mechanical ventilation.

摘要: Background: Papillary thyroid cancer (PTC) presents with local and distant metastases more frequently in children than adults. However, hypoxemia secondary to pulmonary has not been reported the literature. Sorafenib is a small-molecule multikinase inhibitor used radioactive iodine (131I)–refractive papillary carcinoma. Patient Findings: An eight-year-old boy presented fever was found have H1N1 viral pneumonia requiring mechanical ventilation antiviral glucocorticoid treatment. After initial improvement, he readmitted one month later because of persistent hypoxemia. A high-resolution computed tomography chest neck revealed multiple 1–4 mm nodules necrotic lymph nodes on right side neck. Left lung wedge resection deep cervical node biopsies were consistent PTC. He underwent total thyroidectomy central dissection postoperatively required prolonged ventilation. Due t...