About one-half of early spontaneous preterm deliveries can be identified by a rapid matrix metalloproteinase-8 (MMP-8) bedside test at the time of mid-trimester genetic amniocentesis.
作者： Sun Min Kim , Roberto Romero , JoonHo Lee , Piya Chaemsaithong , Min-Woo Lee
DOI: 10.3109/14767058.2015.1094049
关键词:
摘要: AbstractObjective: Mid-trimester amniocentesis continues to be used for the prenatal diagnosis of chromosomal anomalies and other genetic disorders. Analysis amniotic fluid obtained at time mid-trimester identifies those patients who are risk early spontaneous preterm delivery. This is based on a solid body evidence that found subclinical intra-amniotic inflammation/infection causally linked birth. Although several biomarkers have been proposed identify inflammation, accumulated data suggest determination matrix metalloproteinase-8 (MMP-8), or neutrophil collagenase, powerful predictor MMP-8 released by inflammatory cells in response microbial products “danger signals”. A rapid point-of-care test has developed determine bedside within 20 min, without requirement laboratory equipment. The objective thi...
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