Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma
作者： Marios Giannakis , Xinmeng Jasmine Mu , Sachet A. Shukla , Zhi Rong Qian , Ofir Cohen
DOI: 10.1016/J.CELREP.2016.03.075
关键词:
摘要: Large-scale genomic characterization of tumors from prospective cohort studies may yield new insights into cancer pathogenesis. We performed whole-exome sequencing of 619 incident colorectal cancers (CRCs) and integrated the results with tumor immunity, pathology, and survival data. We identified recurrently mutated genes in CRC, such as BCL9L, RBM10, CTCF, and KLF5, that were not previously appreciated in this disease. Furthermore, we investigated the genomic correlates of immune-cell infiltration and found …
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