Growth hormone and bone.

摘要: Bone and mineral metabolism is regulated by numerous hormones local growth factors. Growth hormone (GH), directly and/or indirectly through IGF1 IGF2 production, stimulates bone turnover as it increases osteoblast number function. It also resorption unknown mechanisms. GH (by IGF1) the renal 25-hydroxyvitamin D-1 alpha-hydroxylase activity therefore enhances calcium phosphate absorption in intestine. maximal tubular reabsorption of phosphate. The overall effect on seems beneficial mass increased together with lean body mass. Large excess GH, however, risk osteoarthritis has other serious metabolic side effects, so that its place treatment/prevention osteoporosis yet to be defined.