The tumor-suppressive microRNA-1/133a cluster targets PDE7A and inhibits cancer cell migration and invasion in endometrial cancer
作者： NORIKO YAMAMOTO , RIKA NISHIKAWA , TAKESHI CHIYOMARU , YUSUKE GOTO , ICHIRO FUKUMOTO
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摘要: In developed countries, endometrial cancer (EC) is the most common malignancy among women. Unopposed estrogen therapy, obesity, nulliparity, diabetes mellitus and arterial hypertension have been linked to an increased risk of EC. However, molecular mechanisms EC oncogenesis metastasis not yet fully elucidated. Our recent studies microRNA (miRNA) expression signatures revealed that microRNA-1/133a (miR‑1/133a) cluster frequently downregulated in various types human cancers. functional role miR‑1/133a cells still unknown. Thus, aim this study was investigate significance its regulated targets, with emphasis on contributions metastasis. We found levels miR‑1 miR‑133a were significantly reduced tissues. Moreover, restoration mature or miRNAs inhibited cell migration invasion, suggesting these clustered act as tumor suppressors. Prediction miRNA targets phosphodiesterase 7A (PDE7A) a potential target gene by both miR‑133a. PDE7A confirmed be overexpressed clinical specimens silencing invasion. data demonstrated downregulation promoted invasion via overexpression cells. Elucidation networks tumor-suppressive will provide insights into
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