Protective antigen complexes with increased stability and uses thereof
作者： Masaru Miyagi , James G. Bann
DOI:
关键词:
摘要: Immunogenic compositions against Bacillus anthracis comprising a stabilized protective antigen complex are disclosed. The comprises protein and capillary morphogenesis protein-2, with the protein-2 being bound to along binding interface. has increased thermal structural stability, resistance premature proteolytic degradation. Methods of using same induce an immunogenic response in subject B. infection also
lens.org 参考文章(6)
James G. Bann, Protective antigen having fluorinated histidine residues United States Patent and Trademark Office. ,(2010)
Alexander S. Williams, Scott Lovell, Asokan Anbanandam, Rahif El-Chami, James G. Bann, Domain 4 of the anthrax protective antigen maintains structure and binding to the host receptor CMG2 at low pH Protein Science. ,vol. 18, pp. 2277- 2286 ,(2009) , 10.1002/PRO.238
Lei Hu, Sangeeta B. Joshi, Kiran K. Andra, Santosh V. Thakkar, David B. Volkin, James G. Bann, C. Russell Middaugh, Comparison of the structural stability and dynamic properties of recombinant anthrax protective antigen and its 2‐fluorohistidine‐labeled analogue Journal of Pharmaceutical Sciences. ,vol. 101, pp. 4118- 4128 ,(2012) , 10.1002/JPS.23294
Jeney Zhang, Eleanor Pritchard, Xiao Hu, Thomas Valentin, Bruce Panilaitis, Fiorenzo G. Omenetto, David L. Kaplan, Stabilization of vaccines and antibiotics in silk and eliminating the cold chain Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 11981- 11986 ,(2012) , 10.1073/PNAS.1206210109
D. Shyamali Wimalasena, Blythe E. Janowiak, Scott Lovell, Masaru Miyagi, Jianjun Sun, Haiying Zhou, Jan Hajduch, Chaya Pooput, Kenneth L. Kirk, Kevin P. Battaile, James G. Bann, Evidence that histidine protonation of receptor-bound anthrax protective antigen is a trigger for pore formation Biochemistry. ,vol. 49, pp. 6973- 6983 ,(2010) , 10.1021/BI100647Z
Fatemeh Chadegani, Scott Lovell, Vennela Mullangi, Masaru Miyagi, Kevin P. Battaile, James G. Bann, 19F Nuclear Magnetic Resonance and Crystallographic Studies of 5-Fluorotryptophan-Labeled Anthrax Protective Antigen and Effects of the Receptor on Stability Biochemistry. ,vol. 53, pp. 690- 701 ,(2014) , 10.1021/BI401405S