Role of water in protein aggregation and amyloid polymorphism.
作者： John E. Straub , Govardhan Reddy , D. Thirumalai
DOI: 10.1021/AR2000869
关键词:
摘要: A variety of neurodegenerative diseases are associated with amyloid plaques, which begin as soluble protein oligomers but develop into amyloid fibrils. Our incomplete understanding of this process underscores the need to decipher the principles governing protein aggregation. Mechanisms of in vivo amyloid formation involve a number of coconspirators and complex interactions with membranes. Nevertheless, understanding the biophysical basis of simpler in vitro amyloid formation is considered important for discovering ligands …
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