Molecular analysis of the structure and function of the angiotensin II type 1 receptor.

摘要: The renin-angiotensin system hormone angiotensin II (Ang II) plays a central role in the pathophysiology of hypertension, cardiac hypertrophy, congestive heart failure, and coronary disease. Two distinct subtypes Ang receptor, type 1 (AT1) 2 (AT2), have been identified, both shown to belong G-protein-coupled receptor superfamily (GPCRs). recent Human Genome Project has revealed more than 1,000 transmembrane (TM) receptors that this superfamily, it estimated 50% all clinically used medicines modulate GPCRs activity. Recently, there many new insights regarding other GPCRs, such as on homo- hetero-oligomerization, constitutive activation, movement TM helices, internalization, desensitization phosphorylation, trafficking, nuclear localization, intracellular protein-induced receptor-associated proteins. Although AT1 antagonists which prevent II-induced signaling are already available, we here summarize findings their structure function, possibility therapeutic strategies for targeting through molecular biological techniques.