Associations of acetylcholinesterase inhibition between pesticide spray seasons with depression and anxiety symptoms in adolescents, and the role of sex and adrenal hormones on gender moderation.

摘要: Cholinesterase inhibitor pesticides, especially organophosphates, are endocrine disruptors and a few existing studies have linked self-reports of exposure with increased depression anxiety. Some evidence suggests that associations may be stronger in women, but the mechanism this gender difference is unclear. We assessed whether acetylcholinesterase (AChE) inhibition between 2 time points (reflecting greater cholinesterase exposure) during different agricultural seasons year was associated anxiety/depression symptoms. examined 300 adolescents (ages 11–17 years, 51% female) living near settings Ecuador (ESPINA study) twice 2016: April July–October. AChE activity (finger stick), estradiol, testosterone, dehydroepiandrosterone, cortisol (saliva) anxiety scales (CDI-2 MASC-2). The mean (SD) scores were 52.8 (9.3) 58.1 (9.6), respectively. median (25th, 75th percentile) change (July–October vs April) − 3.94% (− 10.45%, 5.13%). For every 10% decrease activity, there 0.96 unit (95% CI 0.01, 1.90) increase symptoms an OR elevated score 1.67 (1.04, 2.66). These girls (OR = 2.72 [1.23, 6.00]) than boys (1.18 [0.59, 2.37]). Adjustment for cortisol, testosterone dehydroepiandrosterone reduced differences by 18–62%. No observed Inhibition at pesticide spray periods symptoms, affecting more boys. Gender partly explained disruption. findings suggest transiently affect mood adolescents.