miR-30e-5p represses angiogenesis and metastasis by directly targeting AEG-1 in squamous cell carcinoma of the head and neck.
作者： Shuiting Zhang , Guo Li , Chao Liu , Shanhong Lu , Qiancheng Jing
DOI: 10.1111/CAS.14259
关键词:
摘要: Metastasis is a critical determinant for the treatment strategy and prognosis in patients with squamous cell carcinoma of head neck (SCCHN). However, mechanisms underlying SCCHN metastasis are poorly understood. Our study sought to determine key microRNA their functional involved metastasis. For The Cancer Genome Atlas (TCGA) data analysis, quantitative PCR was used quantify level miR-30e-5p its clinical significance further analyzed. A series vitro vivo experiments were applied effects target AEG-1 on mechanism investigation revealed that implicated angiogenesis mediated by miR-30e-5p. Overall, our confirms valuable predictive biomarker potential therapeutic
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