Bioactive sesquiterpene quinols and quinones from the marine sponge Dysidea avara
作者： Wei-Hua Jiao , Ting-Ting Xu , Bin-Bin Gu , Guo-Hua Shi , Yan Zhu
DOI: 10.1039/C5RA18876H
关键词:
摘要: Four new sesquiterpene quinols, dysiquinols A–D (1–4), and four quinones, (5S,8S,9R,10S)-18-ethoxyneoavarone (5), (5S,8S,9R,10S)-19-ethoxyneoavarone (6), (5R,8R,9S,10R)-18-ethoxyavarone (7), (5R,8R,9S,10R)-19-ethoxyavarone (8), together with a known compound, avarol (9), were isolated from the South China Sea marine sponge Dysidea avara. The planar structures of compounds elucidated by interpretation HRESIMS 2D NMR spectroscopic data, their absolute configurations determined comparison between calculated experimental ECD spectra. cytotoxicity 1–9 against human myeloma cancer cell line NCI-H929 NF-κB inhibitory activity evaluated. Among these metabolites, dysiquinol D (4) showed most potent cytotoxic activities IC50 values 2.8 0.81 μM, respectively.
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