Liquid chromatography-tandem mass spectrometry of bioactive pharmaceutical compounds in the aquatic environment--a decade's activities.

摘要: The occurrence of bioactive pharmaceutical compounds in the aquatic environment is an emerging concern. Liquid chromatography, coupled with mass spectrometry (LC–MS) or tandem (LC–MS–MS) using electrospray ionization interface, a crucial tool for addressing this issue. We review manuscript LC–MS and LC–MS–MS studies on waterborne PhACs last decade, including research activity different geographical areas current status technology used sample preparation, chromatographic separation, spectrometric detection. A detailed overview quality-control quality-assurance (QC/QA) procedures also presented, emphasis need concerted approach to determine numerical values associated detection limits, use low-level data qualifiers.