摘要: Almost 3 decades have passed since the discovery and cloning of IL-6, a tremendous amount work has contributed to current knowledge biological functions this cytokine, its receptor, signaling pathways that are activated. The understanding role IL-6 in human disease led development novel therapeutic strategies block IL-6. In clinical studies, receptor antibodies proven efficacy rheumatoid arthritis, systemic juvenile idiopathic Castleman's disease, conditions known be driven by focus overview is pathophysiology hematological malignancies.
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