Pneumococcal Serotype Diversity among Adults in Various Countries, Influenced by Pediatric Pneumococcal Vaccination Uptake
作者： J. D. Grabenstein , D. J. Weber
DOI: 10.1093/CID/CIT800
关键词:
摘要: Streptococcus pneumoniae serotypes differ in clinical manifestations among adults. Indirect effects of pediatric use pneumococcal conjugate vaccines (PCVs) affect rates adult serotype-specific invasive disease (IPD). To characterize PCV effect on serotype patterns, we reviewed the literature for differences proportions and incidence matching 23-valent polysaccharide vaccine (PPSV23) 13-valent within specified geographic time conditions. For IPD distribution before widespread PCV7 use, median differential between 23 13 was 16.3% core analysis. After adoption, 24.4% (P < .003).The adults 5.6 cases per 100 000 population 6.4 afterward = .52). The alternate helps explain recent national recommendations one or both various populations. These may widen further, with more extensive uptake higher-valence PCVs.
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