Impact of Eukaryotic Translation Initiation Factors on Breast Cancer: Still Much to Investigate.
作者： Qin Chen , Bo Yang , Norbert Nass , Christoph Schatz , Johannes Haybaeck
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摘要: Breast carcinoma (BC) remains one of the most serious health problems. It is a heterogeneous entity, and mainly classified according to receptor status for estrogen (ER), progesterone (PR) egf (HER2/Neu), as well proliferation marker ki67. Gene expression in eukaryotes regulated at level both gene transcription translation, where eukaryotic initiation factors (eIFs) are key regulators protein biosynthesis. Aberrant translation results an altered cellular proteome, this clearly effects cell growth supporting tumorigenesis. The relationship between various eIFs BC entities, related regulatory mechanisms, has meanwhile become focus scientific interest. Here, we give overview on current research state eIF function, focusing BC.
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