P2X purinergic receptors and exocrine glands.

摘要: Purinergic P2X receptors are widely expressed in acinar and ductal cells of exocrine glands. Several studies provide evidence for the expression P2X1, P2X4 and/or P2X7 receptors. These non-selective cation channels activated by ATP which can be released glands themselves, following various stimuli like cholinergic stimulation. The receptor is unique because its long intracellular C-terminal domain, allowing interaction this with proteins. partly localized lipid rafts. Their activation modulates activity enzymes involved phospholipid signalling thus effectors. Here we give an overview recent have now confirmed involvement gland pathways, taking place host defence secretion.