Navigator-triggered oxygen-enhanced MRI with simultaneous cardiac and respiratory synchronization for the assessment of interstitial lung disease.

摘要: Purpose To evaluate an optimized method for oxygen-enhanced MRI of the lung, using simultaneous electrocardiograph (ECG) and navigator triggering. To correlate with lung function tests assessing alveolar-capillary gas exchange. Materials Methods A total 12 healthy volunteers (aged 20–32 years) 10 patients 37–87 interstitial diseases (ILD) underwent pulmonary functional (PFTs) exchange. The paradigm room-air–oxygen–room-air was acquired a nonselective inversion-recovery half-Fourier single-shot turbo spin-echo sequence (inversion time = 1200 msec; acquisition 134.5 slice thickness 20 mm; matrix size 128 × 128), double triggering (navigator plus ECG trigger). Cross-correlation performed in regions interest (ROIs) encompassing both lungs. number oxygen-activated pixels over ROIs (OAP%) compared. OAP%s were correlated PFTs. Results The mean OAP% significantly lower than that (36.7 vs. 81.7, P 0.001). transfer factor carbon monoxide (Tlco) (r 0.64; 0.002), coefficient (Kco) 0.75; 0.001), arterial partial pressure 0.77; < saturation 0.70; 0.001) oxygen. Conclusion Navigator-triggered may have potential role quantitative assessment ILD. J. Magn. Reson. Imaging 2007. © 2007 Wiley-Liss, Inc.