SIRT2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors.
作者： Toshiaki Inoue , Yuji Nakayama , Yanze Li , Haruka Matsumori , Haruka Takahashi
DOI: 10.1111/FEBS.12810
关键词:
摘要: Mitotic catastrophe, a form of cell death that occurs during mitosis and after mitotic slippage to a tetraploid state, plays important roles in the efficacy of cancer cell killing by microtubule …
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