New routes in frontotemporal dementia drug discovery.
作者： Laura De Conti , Barbara Borroni , Marco Baralle
DOI: 10.1080/17460441.2017.1329294
关键词:
摘要: ABSTRACTIntroduction: Research into the pathogenic mechanisms behind frontotemporal dementia (FTD) has yielded several new targets for therapeutic intervention; such include specific pathways uncovered by mutations as well involving modulation, formation and degradation of protein aggregates.Areas covered: Herein, authors outline principal molecular causes underlying FTD to date research that been performed in these areas with respect an eventual corrective strategy.Expert opinion: While it is worthwhile targeting affected a causative loss function linked FTD, still contend issues including remaining presence aggregates or treatments are rarely universally applicable. Aiming recover downstream target caused will likely be insufficient due large cascade events affected. It our belief clearance aggregate...
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