Antidopaminergic effects of dietary tyrosine depletion in healthy subjects and patients with manic illness.

摘要: Background In rats, amino acid mixtures lacking tyrosine and its precursor phenylalanine decrease the release of dopamine produced by psychostimulant drug amphetamine. Amphetamine has been proposed as a model for clinical mania. Aims To assess whether dietary depletion attenuates effects methamphetamine in healthy volunteers diminishes severity mania acutely ill patients. Method Sixteen received tyrosine-free mixture control double-blind crossover design 4 h before (0.15 mg/kg). Twenty in-patients meeting DSM-IV criteria were allocated blindly randomly to receive either or mixture. Results The lowered both subjective objective measures ofthe methamphetamine. Ratings lower patients who Conclusions Decreased availability brain pathological increases neurotransmission following administration putatively Declaration interest study was supported grant from WellcomeTrustto M.H.M. Nuffield Research Fellow, S.F.B.M. an MRCClinical Training Fellow P.J.C. T.S. are Scientists.