Increasing incidence in liver cancer in Canada, 1972–2006: Age-period-cohort analysis

摘要: Background/Aims: Our study aimed to assess 1) the temporal trends in incidence and mortality of liver cancer 2) age-period-cohort effects on Canada. Methods: We analyzed data obtained from Canadian Cancer Registry Database Vital Statistics Death Database. first examined by sex, age group, birth cohort between 1972 2006. Three–year period rates annual percentage change (APC) were calculated compare changes over period. used modelling estimate underlying observed incidence. Results: The overall age-adjusted increased 2.6 1.5 per 100 000 1972–74 6.5 (APC: 2.9) 2.2 1.2) 2004–06 among males females, respectively. 3.3 2.0 6.0 2.3) most rapidly men aged 45–54 years 4.1) women 65–74 1.7) study. Conclusions: analysis suggests that birth-cohort effect is increase incidence. While exact reason for remains unknown, reported HBV HCV infections, immigration high-risk regions world may be important factors.