Virus diversity in a winter epidemic of acute diarrhea in France.

摘要: In France, an epidemic peak of acute diarrhea is observed each winter. Previous results suggested a viral etiology for these winter epidemics. We investigated the role enteric viruses in and their molecular diversity. One hundred sixty-one patients with 45 healthy (controls) from general population were given standardized questionnaire between December 1998 May 1999. Stool specimens screened group A C rotaviruses, human caliciviruses, astroviruses, adenovirus types 40 41 by reverse transcription-PCR and/or enzyme immunoassay. Virologic analysis was positive 63 cases (39%). Caliciviruses rotaviruses most frequent (19 17% cases, respectively). Two control stool found rotavirus, one astrovirus. Molecular characterization strains disclosed cocirculation P[8],G1, P[8],G4, P[4],G2 rotaviruses; type 1, 2, 3, 4, 8 astroviruses; Sapporo-like Norwalk-like caliciviruses. These four accounted attributable risk 34.7% population, under assumption causal viruses.