Effects of SHBG rs1799941 Polymorphism on Free Testosterone Levels and Hypogonadism Risk in Young Non-Diabetic Obese Males

摘要: Introduction: Obesity has been associated with increased risk of presenting hypogonadism. Free testosterone (FT) is the fraction that carries out biological function testosterone, and determined from total (TT) sex-hormone binding globulin (SHBG) levels. We aimed to study SHBG polymorphism rs1799941 in a cohort young non-diabetic obese males unravel possible implication this obesity-related Methodology: 212 ( 3.5 ng/mL FT ≥ 70 pg/mL; EuG), normal hypogonadism (n = 40, TT < HG) 117, TL HG). The (GG/GA/AA) was analyzed using Taqman Open Array (Applied biosystem). Results: frequencies were different among groups. Higher proportion allele (A) found HG, compared EuG HG. Among genotypes, rare homozygous (AA) HG group higher levels serum lower observed. presence A related (according lineal regression models) an ((GA) β 3.28; 12.45) decreased −9.19; −18.52). (OR 2.54). Conclusions: gene can partially determine whether these subjects have