Public resources for chemical probes: the journey so far and the road ahead

Wen Hwa Lee, Open Access Target Validation Is a More Efficient Way to Accelerate Drug Discovery PLOS Biology. ,vol. 13, ,(2015) , 10.1371/JOURNAL.PBIO.1002164

Cheryl H Arrowsmith, James E Audia, Christopher Austin, Jonathan Baell, Jonathan Bennett, Julian Blagg, Chas Bountra, Paul E Brennan, Peter J Brown, Mark E Bunnage, Carolyn Buser-Doepner, Robert M Campbell, Adrian J Carter, Philip Cohen, Robert A Copeland, Ben Cravatt, Jayme L Dahlin, Dashyant Dhanak, Aled M Edwards, Mathias Frederiksen, Stephen V Frye, Nathanael Gray, Charles E Grimshaw, David Hepworth, Trevor Howe, Kilian V M Huber, Jian Jin, Stefan Knapp, Joanne D Kotz, Ryan G Kruger, Derek Lowe, Mary M Mader, Brian Marsden, Anke Mueller-Fahrnow, Susanne Müller, Ronan C O'Hagan, John P Overington, Dafydd R Owen, Saul H Rosenberg, Ruth Ross, Bryan Roth, Matthieu Schapira, Stuart L Schreiber, Brian Shoichet, Michael Sundström, Giulio Superti-Furga, Jack Taunton, Leticia Toledo-Sherman, Chris Walpole, Michael A Walters, Timothy M Willson, Paul Workman, Robert N Young, William J Zuercher, The promise and peril of chemical probes. Nature Chemical Biology. ,vol. 11, pp. 536- 541 ,(2015) , 10.1038/NCHEMBIO.1867

Alan R. Williamson, Creating a structural genomics consortium. Nature Structural & Molecular Biology. ,vol. 7, pp. 953- 953 ,(2000) , 10.1038/80726

Dilyana Dimova, Jürgen Bajorath, Computational chemical biology: identification of small molecular probes that discriminate between members of target protein families. Chemical Biology & Drug Design. ,vol. 79, pp. 369- 375 ,(2012) , 10.1111/J.1747-0285.2011.01297.X

Christopher P Austin, Linda S Brady, Thomas R Insel, Francis S Collins, NIH Molecular Libraries Initiative. Science. ,vol. 306, pp. 1138- 1139 ,(2004) , 10.1126/SCIENCE.1105511

Peter J Brown, Susanne Müller, Open access chemical probes for epigenetic targets. Future Medicinal Chemistry. ,vol. 7, pp. 1901- 1917 ,(2015) , 10.4155/FMC.15.127

Stuart L. Schreiber, Joanne D. Kotz, Min Li, Jeffrey Aubé, Christopher P. Austin, John C. Reed, Hugh Rosen, E. Lucile White, Larry A. Sklar, Craig W. Lindsley, Benjamin R. Alexander, Joshua A. Bittker, Paul A. Clemons, Andrea de Souza, Michael A. Foley, Michelle Palmer, Alykhan F. Shamji, Mathias J. Wawer, Owen McManus, Meng Wu, Beiyan Zou, Haibo Yu, Jennifer E. Golden, Frank J. Schoenen, Anton Simeonov, Ajit Jadhav, Michael R. Jackson, Anthony B. Pinkerton, Thomas D.Y. Chung, Patrick R. Griffin, Benjamin F. Cravatt, Peter S. Hodder, William R. Roush, Edward Roberts, Dong-Hoon Chung, Colleen B. Jonsson, James W. Noah, William E. Severson, Subramaniam Ananthan, Bruce Edwards, Tudor I. Oprea, P. Jeffrey Conn, Corey R. Hopkins, Michael R. Wood, Shaun R. Stauffer, Kyle A. Emmitte, Linda S. Brady, Jamie Driscoll, Ingrid Y. Li, Carson R. Loomis, Ronald N. Margolis, Enrique Michelotti, Mary E. Perry, Ajay Pillai, Yong Yao, Advancing Biological Understanding and Therapeutics Discovery with Small Molecule Probes Cell. ,vol. 161, pp. 1252- 1265 ,(2015) , 10.1016/J.CELL.2015.05.023

Gabriel M Simon, Micah J Niphakis, Benjamin F Cravatt, Determining target engagement in living systems Nature Chemical Biology. ,vol. 9, pp. 200- 205 ,(2013) , 10.1038/NCHEMBIO.1211

Paul Workman, Bissan Al-Lazikani, Drugging cancer genomes Nature Reviews Drug Discovery. ,vol. 12, pp. 889- 890 ,(2013) , 10.1038/NRD4184

Stephen V Frye, The art of the chemical probe Nature Chemical Biology. ,vol. 6, pp. 159- 161 ,(2010) , 10.1038/NCHEMBIO.296