Effect of water-soluble polymers on the physical stability of aqueous polymeric dispersions and their implications on the drug release from coated pellets.
作者： Andrei Dashevsky , Abid Riaz Ahmed , J Mota , Muhammad Irfan , Karl Kolter
DOI: 10.3109/03639040903410334
关键词:
摘要: Purpose: To investigate the physical stability and drug release-related properties of aqueous polymer dispersions Kollicoat® SR 30 D Aquacoat® ECD (an ethylcellulose-based dispersion) in presence water-soluble polymers (pore formers) with special attention to potential flocculation dispersions. Methods: A precise characterization phenomena undiluted samples was monitored turbidimetric measurements using Turbiscan Lab-Expert. Theophylline or propranolol HCl drug-layered pellets were coated by addition polyvinyl pyrrolidone (Kollidon® 90 F), alcohol–polyethylene glycol graft copolymer (Kollicoat® IR), hydroxypropyl methylcellulose (Pharmacoat® 603 606) a fluidized bed coater Glatt GPCG-1 release performed according UPS paddle method. Results: Stable obtained both (a acetate-based di...
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