Hemotoxicity of carbon nanotubes

作者: Cyrill Bussy , Laura Methven , Kostas Kostarelos

DOI: 10.1016/J.ADDR.2013.10.008

关键词:

摘要: Carbon nanotubes may enter into the bloodstream and interact with blood components indirectly via translocation following unintended exposure or directly after an intended administration for biomedical purposes. Once introduced systemic circulation, will encounter various proteins, biomolecules cells which have specific roles in homeostasis of circulatory system. It is therefore essential to determine whether those interactions lead adverse effects not. Advances understanding how carbon complement system, red hemostatic system are reviewed this article. While many studies on nanotube health risk assessment their applications appeared last few years, reports hemocompatibility these nanomaterials remain surprisingly limited. Yet, defining hemotoxicological profile a mandatory step toward development clinically-relevant medications contrast agents based nanotubes.

参考文章(66)
Maurizio Prato, Kostas Kostarelos, Alberto Bianco, Functionalized carbon nanotubes in drug design and discovery. Accounts of Chemical Research. ,vol. 41, pp. 60- 68 ,(2008) , 10.1021/AR700089B
Elena V. Basiuk, Vladimir A. Basiuk, Malcolm L. H. Green, Robert B. Sim, Carolina Salvador-Morales, Effects of covalent functionalization on the biocompatibility characteristics of multi-walled carbon nanotubes. Journal of Nanoscience and Nanotechnology. ,vol. 8, pp. 2347- 2356 ,(2008) , 10.1166/JNN.2008.090
Tapas R. Nayak, Li Jian, Lee C. Phua, Han K. Ho, Yupeng Ren, Giorgia Pastorin, Thin Films of Functionalized Multiwalled Carbon Nanotubes as Suitable Scaffold Materials for Stem Cells Proliferation and Bone Formation ACS Nano. ,vol. 4, pp. 7717- 7725 ,(2010) , 10.1021/NN102738C
Wai Li Ling, Adrienn Biro, Isabelle Bally, Pascale Tacnet, Aurélien Deniaud, Eric Doris, Philippe Frachet, Guy Schoehn, Eva Pebay-Peyroula, Gérard J. Arlaud, Proteins of the Innate Immune System Crystallize on Carbon Nanotubes but Are Not Activated ACS Nano. ,vol. 5, pp. 730- 737 ,(2011) , 10.1021/NN102400W
Tatsuya Murakami, Hirotaka Nakatsuji, Mami Inada, Yoshinori Matoba, Tomokazu Umeyama, Masahiko Tsujimoto, Seiji Isoda, Mitsuru Hashida, Hiroshi Imahori, Photodynamic and photothermal effects of semiconducting and metallic-enriched single-walled carbon nanotubes. Journal of the American Chemical Society. ,vol. 134, pp. 17862- 17865 ,(2012) , 10.1021/JA3079972
Silvia H. De Paoli Lacerda, Jana Semberova, Karel Holada, Olga Simakova, Steven D. Hudson, Jan Simak, Carbon Nanotubes Activate Store-Operated Calcium Entry in Human Blood Platelets ACS Nano. ,vol. 5, pp. 5808- 5813 ,(2011) , 10.1021/NN2015369
Barry W. Neun, Marina A. Dobrovolskaia, Method for in vitro analysis of nanoparticle thrombogenic properties. Methods of Molecular Biology. ,vol. 697, pp. 225- 235 ,(2011) , 10.1007/978-1-60327-198-1_24
Barry W. Neun, Marina A. Dobrovolskaia, Qualitative Analysis of Total Complement Activation by Nanoparticles Methods of Molecular Biology. ,vol. 697, pp. 237- 245 ,(2011) , 10.1007/978-1-60327-198-1_25
Marina A. Dobrovolskaia, Jeffrey D. Clogston, Barry W. Neun, Jennifer B. Hall, Anil K. Patri, Scott E. McNeil, Method for analysis of nanoparticle hemolytic properties in vitro. Nano Letters. ,vol. 8, pp. 2180- 2187 ,(2008) , 10.1021/NL0805615
Dimitrios Tasis, Nikos Tagmatarchis, Alberto Bianco, Maurizio Prato, Chemistry of Carbon Nanotubes Chemical Reviews. ,vol. 106, pp. 1105- 1136 ,(2006) , 10.1021/CR050569O