Screening lifespan-extending drugs in Caenorhabditis elegans via label propagation on drug-protein networks

摘要: One of the most challenging tasks in exploration anti-aging is to discover drugs that can promote longevity and delay incidence age-associated diseases human. Up date, a number drugs, including some antioxidants, metabolites synthetic compounds, have been found effectively aging nematodes insects. We proposed label propagation algorithm on drug-protein network infer extend lifespan C. elegans. collected set which functions extension elegans reliably determined, then built large-scale by collecting high-confidence drugprotein interactions. A was run bipartite predict new with lifespan-extending effect calibrated performance method conducting comparison two classical models, kNN SVM. also showed screened significantly mediate aging-related pathways, higher chemical similarities effective than ineffective promoting Moreover, we carried out wet-lab experiments verify 2- Bromo-4’-nitroacetophenone, it These results our screening lifespanextending In this paper, semi-supervised effects silico empirical evaluations vivo demonstrated narrow down scope candidate needed be verified wet lab experiments.