Redox biology of tuberculosis pathogenesis.

摘要: Mycobacterium tuberculosis (Mtb) is one of the most successful human pathogens. Mtb persistently exposed to numerous oxidoreductive stresses during its pathogenic cycle infection and transmission. The distinctive ability Mtb, not only survive redox stress manifested by host but also use it for synchronizing metabolic pathways expression virulence factors, central success as a pathogen. This review describes paradigmatic hypoxia sensors employed continuously monitor variations in intracellular state surrounding microenvironment. Two component proteins, namely, DosS DosT, are sense changes oxygen, nitric oxide, carbon monoxide levels, while WhiB3 anti-sigma factor RsrA used state. Using these other unidentified sensors, orchestrates nutrient-deficient, acidic, oxidative, nitrosative, hypoxic environments inside granulomas or infectious lesions. A number unique mycobacteria thus represent potential drug targets. In addition, employs versatile machinery mycothiol thioredoxin systems ensure reductive environment optimal functioning proteins even upon exposure oxidative stress. utilizes battery protective enzymes, such superoxide dismutase (SOD), catalase (KatG), alkyl hydroperoxidase (AhpC), peroxiredoxins, neutralize generated immune system. chapter reviews current understanding mechanisms their importance TB pathogenesis development.