Intermittent Dopaminergic Stimulation causes Behavioral Sensitization in the Addicted Brain and Parkinsonism

摘要: The gold standard therapy for Parkinson's disease (PD) consists in chronic administration of pulses the dopamine (DA) precursor l -dihydroxyphenylalanine ( -DOPA). Although main brain area which is DA-deficient dorsal striatum (more putamen than caudate nucleus), other DA-innervated regions (i.e., ventral and limbic areas) are affected by systemic -DOPA. While such a produces an increase synaptic nonsynaptic DA, replace neurotransmitter deficiency, peaks extracellular DA course progression produce abnormal involuntary movements related to behavioral sensitization. Methamphetamine (METH), widely abused drug, known sensitization, release as well regions). present review discusses overlapping between these treatments, based on stimulation with emphasis class receptors; signal transduction pathways; rearranged expression neurotransmitters, cotransmitters, their receptors coupled ultrastructural changes. In fact, all levels plasticity show surprising homology following posing mechanisms sensitization during DA-replacement PD very close neurobiological operating METH abuse. line this view growing evidence addictive behaviors patients therapy.