Mesothelioma mortality in asbestos workers: implications for models of carcinogenesis and risk assessment.

摘要: Mesothelioma death rates in asbestos workers appear to be proportional the 3rd or 4th power of time from first exposure under a wide range conditions for both pleural and peritoneal tumours, though peritoneal:pleural ratio depends on fibre dimension type. Age at has little no influence, however, which supports "multi-stage" model carcinogenesis increase most cancer incidence with age is due constant genetic epigenetic accidents, rather than progressive generalized changes regulatory immune function. These relationships provide simple basis risk assessment, support suggestion that mesotheliomas may constitute high proportion deaths resulting early asbestos.