KIAA1522 is a novel prognostic biomarker in patients with non-small cell lung cancer

摘要: Nowadays, no robust biomarkers have been applied to clinical practice provide prognostic evaluation of non-small cell lung cancer (NSCLC). This study aims identify new potential for NSCLC. In the present work, KIAA1522 is screened out from two independent GEO datasets as aberrantly up-regulated gene in NSCLC tissues. We evaluate expression immunohistochemically 583 tissue samples and paired non-tumor displays stronger staining cases than adjacent normal Importantly, patients with overexpression had a significantly shorter overall survival compared those low (P < 0.00001). Multivariate Cox regression analyses show that an indicator, even early-stage NSCLCs (P = 0.00025, HR = 2.317, 95%CI: 1.477-3.635). also found high significant risk factor decreased who received platinum-based chemotherapy. Gene set enrichment analysis (GSEA) functional studies reveal associated oncogenic KRAS pathways. Taken together, can be used biomarker predication poor platinum-resistance patients, aberrant might target therapy disease.