Next generation ultrasound platforms for theranostics

摘要: Microbubbles are a well-established contrast agent which improves diagnostic ultrasound imaging. During the last decade research has focused on expanding their use to include molecular imaging, targeted therapy and imaging modalities other than ultrasound. However, bioadhesion of microbubbles under physiological flow conditions is still difficult achieve, main challenge being connected poor stability lipid in body’s circulation system. In this article, we investigate polymeric based poly (vinyl alcohol) shell as an alternative microbubbles. particular, report development microbubble modification, using mild reaction conditions, with aim designing multifunctional platform enable diagnosis therapy. Superparamagnetic iron oxide nanoparticles near infrared fluorescent probe, indocyanine green, coupled bubbles surface order support magnetic resonance fluorescence Furthermore, anchoring cyclic arginyl-glycyl-aspartic acid (RGD) peptide, cyclodextrin molecules, allows targeting drug loading, respectively. Last but not least, topography provided by atomic force microscopy. These applications features, together high echogenicity microbubbles, may offer more stable for multimodal theranostic platform.