Aminoacid parenteral infusion soln. - for hepatic coma treatment contg. relatively high concns. of arginine, ornithine, glutamic acid and aspartic acid

摘要: New aminoacid soln. for parenteral infusion contains an amino acid mixt. of the following compsn.: 3.0+/-1.6 wt.parts L-aspartic acid; 4.6+/-0.8 L-threonine; 2.7+/-1.1 L-serine; 7.1+/-2.5 L-proline; 5.7+/-2.8 L-glutamic 6.3+/-1.5 L-glycine; 8.3+/-2.2 L-alanine; 10.4+/-1.5 L-valine; 2.0+/-1.0 L-cysteine; 0.8+/-0.4 L-methionine; 8.6+/-2.9 L-isoleucine; 13.4+/-2.4 L-leucine; 0.7+/-0.4 L-tyrosine; 1.6+/-1.0 L-phenylalanine; 7.5+/-2.0 L-lysine; 4.7+/-1.4 parts L-histidine; 1.5+/-0.9 L-tryptophan; 8.8+/-2.7 L-arginine; and 1.3+/-0.3 L-ornithine. Used treatment cerebral function disorders caused by hepatic insufficiency (i.e. coma). The onset clinical effects is faster effect longer lasting than with known compsns. coma. on coma accompanied a lowering elevated blood ammonia levels, attributed to presence in relatively high concns. acids urea cycle (e.g. arginine ornithine), as well glutamic aspartic acids.