Synthesis of (R)-Dihydropyridones as Key Intermediates for an Efficient Access to Piperidine Alkaloids
作者： Evangelia Tzanetou , Konstantinos Kasiotis , Prokopios Magiatis , Serkos Haroutounian
DOI: 10.3390/12040735
关键词:
摘要: The efficient transformation of D-glucal to (2R)-hydroxymethyldihydropyridinone 5 in seven steps and 35 % overall yield is reported. Dihydropyridone constitutes a versatile chiral building block for the synthesis various piperidine alkaloids. In this regard, was converted piperidinol 13 piperidinone 15, that may be further elaborated syntheses (+)-desoxoprosophylline (1) deoxymannojirimycin (3) or D-mannolactam (4), respectively.
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