Structural Analysis of Dynein Intermediate and Light Chains

摘要: Publisher Summary This chapter focuses on the structural and biochemical investigations of light chains (LCs) intermediate (ICs) dynein protein. It addresses promiscuity LCs LC8 Tctex1, as well their potential role in function. Since much efforts focus cytoplasmic dynein, particular animal origin (rat drosophila), study primarily concentrates dynein. uses information from other complexes to illustrate differences among different family members. provides an abbreviated background LCs, also discussing structure Apo liganded chains. Furthermore, it illustrates molecular model chain–intermediate chain describes post-translational modifications Structural initially performed understand context provide compelling evidence that do not bridge cargo but rather play important roles assembly complex (e.g., LC7) potentially regulation N-terminus IC Tctex1).