Catsper3 and Catsper4 Are Essential for Sperm Hyperactivated Motility and Male Fertility in the Mouse
作者： Jingling Jin , Nange Jin , Huili Zheng , Seungil Ro , Dora Tafolla
DOI: 10.1095/BIOLREPROD.107.060186
关键词:
摘要: Catsper3 and Catsper4 are two recently identified testis-specific genes homologous to Catsper1 Catsper2 that have been shown play an essential role in sperm hyperactivated motility male fertility mice. Here we report knockout mice completely infertile due a quick loss of lack under capacitating conditions. Our data demonstrate both CATSPER3 CATSPER4 required for during capacitation fertility. The present study also demands revisit the idiopathic infertility patients who show normal counts initial defects potential CATSPER gene mutations. channel may be excellent drug target contraceptives.
oup.com
biolreprod.org参考文章(38)
Masaaki Morisawa, Cell signaling mechanisms for sperm motility. Zoological Science. ,vol. 11, pp. 647- 662 ,(1994)
H C Ho, S S Suarez, Hyperactivation of mammalian sperm. Cellular and Molecular Biology. ,vol. 49, pp. 351- 356 ,(2003)
Paul M. Wassarman, Luca Jovine, Eveline S. Litscher, A profile of fertilization in mammals. Nature Cell Biology. ,vol. 3, pp. 59- 64 ,(2001) , 10.1038/35055178
H. Qi, M. M. Moran, B. Navarro, J. A. Chong, G. Krapivinsky, L. Krapivinsky, Y. Kirichok, I. S. Ramsey, T. A. Quill, D. E. Clapham, All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 1219- 1223 ,(2007) , 10.1073/PNAS.0610286104
David R. White, R. John Aitken, Relationship between calcium, cyclic AMP, ATP, and intracellular pH and the capacity of hamster spermatozoa to express hyperactivated motility. Gamete Research. ,vol. 22, pp. 163- 177 ,(1989) , 10.1002/MRD.1120220205
T. A. Quill, D. Ren, D. E. Clapham, D. L. Garbers, A voltage-gated ion channel expressed specifically in spermatozoa. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 12527- 12531 ,(2001) , 10.1073/PNAS.221454998
Anne E. Carlson, Timothy A. Quill, Ruth E. Westenbroek, Sonya M. Schuh, Bertil Hille, Donner F. Babcock, Identical phenotypes of CatSper1 and CatSper2 null sperm. Journal of Biological Chemistry. ,vol. 280, pp. 32238- 32244 ,(2005) , 10.1074/JBC.M501430200
T. A. Quill, S. A. Sugden, K. L. Rossi, L. K. Doolittle, R. E. Hammer, D. L. Garbers, Hyperactivated sperm motility driven by CatSper2 is required for fertilization Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 14869- 14874 ,(2003) , 10.1073/PNAS.2136654100
Han-Chen Ho, Katherine A. Granish, Susan S. Suarez, Hyperactivated motility of bull sperm is triggered at the axoneme by Ca2+ and not cAMP. Developmental Biology. ,vol. 250, pp. 208- 217 ,(2002) , 10.1006/DBIO.2002.0797
Parvaneh Nikpoor, S Javad Mowla, Mansoureh Movahedin, S Amir‐Mohsen Ziaee, Taki Tiraihi, CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility Human Reproduction. ,vol. 19, pp. 124- 128 ,(2004) , 10.1093/HUMREP/DEH043