Pathological circadian rhythm states driven by CK2 and noise

摘要: Abstract Circadian rhythm maintains sleep–wake cycle in living systems. Disruption of this may cause diseases. We propose an extended Drosophila circadian model incorporating cross-talk CK2 with Per protein. studied the using stochastic simulation algorithm, and behavior amplitude, time period permutation entropy us identify three distinct states namely, active, weak activity, activity rhythmic death all driven by CK2. These correspond to pathological cellular system. Noise, important factor, has ability switch normal any aforementioned states. Fluctuations system’s size, can help deterning extent noise present. also highlighted that disruption lead various diseases including cancer. present pathways per mutant genes their Statement significance rhythm, which is one most biological regulates intervenes processes. Significant changes dynamics trigger In work, impact via gene mutants on investigated, found states, Noise due intrinsic random molecular events size variability have capability regulating controlling properties, then listed possible are regulated corresponding