High-yield syntheses of dilithio-derivatives of furan, thiophen, N-methylpyrrole, 3-methylfuran, and 3-methylthiophen. Application of the method to 2-methylfuran, 2-methylthiophen, 2,5-dimethylfuran, 2,5-dimethylthiophen, benzo[b]furan, benzo[b]thiophen, pyrrole, and indole
作者： Derek J. Chadwick , Charles Willbe
DOI: 10.1039/P19770000887
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摘要: Conditions are established for the preparation in yields approaching quantitative of 2,5-dilithio-furan and -thiophen. The effects changes reaction conditions on rates hydrogen–lithium exchange furan thiophen have been investigated discussed detail. appearance a 2,4-dilithio-intermediate, peculiar to N-methyl-pyrrole, has explored, optimum presented syntheses both 2,4- 2,5-intermediates. 3-Methylfuran 3-melhylthiophen similar parent heterocycles their properties. results applying procedure found produce high dilithio-products further eight described.
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