Evaluation of a new benzothiazole derivative with antioxidant activity in the initial phase of acetaminophen toxicity

摘要: Abstract Increasing evidence indicates that benzothiazoles and thioureas have the ability to inactivate reactive chemical species through their antioxidant activity. In this context, we designed synthesized two benzothiazole-isothiourea derivatives, (E)-5-((benzo[d]thiazol-2-ylimino)(methylthio)methylamino)-2-hydroxybenzoic acid (compound 1) (S,E)-2-((benzo[d]thiazol-2-ylimino)(methylthio)methylamino)-3-(4-hydroxyphenyl) propanoic 2). The 2,2′-diphenyl-1-picrylhydrazyl radical reduction Fenton reaction were used evaluate free scavenging activity of both compounds in vitro. results indicated compound 1 exhibited highest Hence, it was evaluated ex vivo using initial phase acetaminophen-induced hepatotoxicity model. particular, demonstrated increased reduced glutathione content decreased malondialdehyde levels. addition, capable inhibiting cytochrome P450 producing a protective effect against intermediary N-acetyl-p-benzoquinoneimine.