Bioequivalence model for evaluation of Losartan in human plasma with special reference to drug-metabolite ratio
作者： Dipanjan Goswami , Sanjay Gurule , Arshad H. Khuroo , Tausif Monif
DOI: 10.3109/10601330903271263
关键词:
摘要: Losartan and in-vivo active metabolite losartan carboxylic acid (LCA) formation into systemic circulation have been poorly characterized in different races. A bioequivalence study was therefore conducted on healthy male Indian volunteers with 50 mg formulation unique comparative analysis other population is presented. Non-compartmental pharmacokinetic elucidated ratio (MR) for losartan: LCA [Cmax = 1.30 AUC 0.32] of more varying compared to innovator 0.82 0.22] though requirements were met successfully. This variation less 100 mg losartan- hydrochlorothiazide our previous published study.
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