Cryptotanshinone inhibits lung tumorigenesis and induces apoptosis in cancer cells in vitro and in vivo.

摘要: Cryptotanshinone is one of the compounds extracted from root Salvia miltiorrhiza Bunge. Unlike other tanshinones, only a small number studies have focused on cryptotanshinone for medical treatment. In present study, A549 lung cancer cell line and xenograft models human tumors were used to assess anti-cancer effect cryptotanshinone. The cancer, including growth inhibition, cycle arrest apoptosis factors, identified in vitro, inhibition tumor formation, improvement body condition as well pathological apoptotic effects detected vivo. These results suggested that potential drug treatment prevention cancer.