The importance of CD25+CD4+ regulatory T cells in mouse hepatic allograft tolerance
作者： Xiaofeng Jiang , Miwa Morita , Atsushi Sugioka , Michishige Harada , Satoshi Kojo
DOI: 10.1002/LT.20787
关键词:
摘要: In mouse liver transplantation, tolerance is readily inducible. Recent studies have revealed that CD25+CD4+ regulatory T cells play an important role in regulating various immune responses, including transplant tolerance. However, the contribution of these to transplantation has not been elucidated. We showed here depletion increased proliferative response CD4+ and cytotoxic lymphocyte induction CD8+ cells. Depletion recipient but donor before caused rejection. Furthermore, number population forkhead/winged helix transcription factor expression mononuclear lymphocytes derived from tolerant mice were higher than those grafts undergoing conclusion, results indicate are for induction. Liver Transpl 12:1112–1118, 2006. © 2006 AASLD.
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