Metabolomic Distinction and Insights Into the Pathogenesis of Human Primary Dilated Cardiomyopathy

摘要: Heart failure affects approximately 23 million individuals worldwide and more than five Americans [1]. is responsible for over one hospitalizations a quarter of deaths per year It the only cardiovascular disease which incidence continues to increase During past two decades, there have been considerable advances in treatment systolic heart failure. The advents angiotensin-1 converting enzyme-1 (ACE-1) inhibitors β blockers reduced mortality by 20% 30%, respectively [2-4]. Despite advances, morbidity patients with remain high comparable many cancers [1]. Primary dilated cardiomyopathy (DCM) prototypic form failure, characterized cardiac dilatation conjunction left ventricular ejection fraction (LVEF). Primary DCM, often caused mutations cytoskeletal sarcomeric proteins [5]. DCM also represents common phenotypic responses various injury or stress, namely, dysfunction. The metabolome has defined as complete profile small molecule metabolites found specific cell, organ organism [6]. Metabolomic analysis potential provide insights into metabolic pathways cells, organs organisms [7]. Metabolomics high-throughput identification, quantification characterization simultaneously could represent cumulative end product gene expression, environmental factors complex multi-faceted interactions between them. lead elucidation molecular involved pathogenesis phenotype hence, identification novel diagnostic markers therapeutic targets. In present study, we analyzed plasma primary normal individuals.